منابع مشابه
Studies in Rodent Poliomyelitis
1. The murine virus may be grown in embryonic mouse brain-serum ultrafiltrate cultures. The virus fails to grow in embryonic chick tissue cultures or in fertilized egg preparations. 2. Some relationship can be demonstrated between the amount of nervous tissue and the infectivity of the culture. 3. Optimum titers of virus potency (10(-6)) can be obtained by adjusting the pH of the growing cultur...
متن کاملStudies in Rodent Poliomyelitis
A description has been given of the lesions produced in mice and guinea pigs by inoculation of the Jungeblut-Sanders virus. The histopathological findings, although in themselves not conclusive, would tend to support the opinion that Jungeblut and Sanders have transmitted the SK poliomyelitis virus to mouse and guinea pig. In mice the virus apparently retains its affinity for the anterior horns...
متن کاملSTUDIES IN RODENT POLIOMYELITIS I. FImTHER EXPERIMENTS WITH THE MURINE STI~AIN OF SK POLIOMYELITIS
In 1940, we reported the successful adaptation of the SK strain of human poliomyelitis virus from the rhesus monkey to white mice by way of intermediary passage through cotton rats (1). A close relationship between the adapted virus and monkey poliomyelitis virus was suggested by similarities in the symptomatology and pathology of the infection in monkeys and rodents as well as by the trend of ...
متن کاملStudies on the Purification of Poliomyelitis Virus
Results of experiments on the preparation of high molecular weight constituents from normal and poliomyelitis-infected medullae-cords are presented. Relatively large yields were obtained from glycerolated normal or infected tissues or from tissues that had been stored at -10 degrees C. for a few days. When the frozen tissues were stored for several weeks, the amount of sedimentable nitrogen iso...
متن کاملStudies on Variants of Poliomyelitis Virus
Attempts were made to "convert" highly virulent strains of the 3 immunologic types of poliomyelitis virus (Mahoney, Y-SK, and Leon) into avirulent variants. Tests involving intracerebral, intramuscular, or oral administration of virus to cynomolgus monkeys indicated that mere propagation in cultures of kidney tissue of cynomolgus monkeys had no effect on virulence when single or small numbers o...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1942
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.76.1.31